Purpose The aim of this study was to develop a novel apixaban-loaded solid self-
emulsifying drug delivery system (S-SEDDS) to enhance oral bioavailability. Methods Oils …

Aim The objective of this study was to enhance the aqueous solubility and oral
bioavailability of nearly water-insoluble apixaban (APX) using polymeric nano-aggregates …

For many years, researchers have been making efforts to find a manufacturing technique, as
well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their …

Phloretin (PHL), a flavonoid of the dihydrogen chalcone class, is reported to have low oral
bioavailability due to its poor solubility and absorption. A common approach to enhance the …

The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol
among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and …

High-shear (HS) melt granulation and hot melt extrusion (HME) were compared as
perspective melt-based technologies for preparation of amorphous solid dispersions …

Drug loading into mesoporous carriers may help to improve the dissolution of poorly
aqueous-soluble drugs. However, both preparation method and carrier properties influence …

In this study, insights into the development and optimization of a co-processed excipient
based on mesoporous silica are presented. The main advantage of such a material is that it …

Probiotics have been used in human and veterinary medicine to increase resistance to
pathogens and provide protection against external impacts for many years. Pathogens are …

Kaempferia parviflora (KP), renowned as an alternative medicine, has gained widespread
acclaim for its efficacy in male sexual enhancement and anti-inflammatory applications …