Daptomycin is a lipopeptide antimicrobial with in vitro bactericidal activity against Gram-
positive bacteria that was first approved for clinical use in 2004 in the United States. Since …

Objective: To summarize current antibiotic dosing recommendations in critically ill patients
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …

Objective: To evaluate evidence for high-dose daptomycin (doses≥ 8 mg/kg/d). Data
Sources: A PubMed/MEDLINE literature search was performed (January 2000 to December …

Severe (life-threatening) meticillin-resistant Staphylococcus aureus (MRSA) infection
continues to be treated with vancomycin despite accumulating evidence of poor outcome …

Purpose: Antibiotics are frequently used in patients receiving intermittent or continuous renal
replacement therapy (RRT). Continuous renal replacement may alter the pharmacokinetics …

Gram-positive cocci are the most common cause of bloodstream infections in hemodialysis
patients, with Staphylococcus aureus and coagulase-negative staphylococci causing most …

Critically ill patients with acute kidney injury may be treated with a variety of renal
replacement therapies (RRTs). Each of these RRTs has profound yet differing effects on …

Objectives Daptomycin is bactericidal against Gram-positive bacteria, with peak-dependent
effect but trough-dependent toxicity. This study was performed to develop dosing …

Although pharmacokinetic changes occurring in kidney disease are well described,
pharmacodynamics in kidney disease is rarely considered. Knowledge of pharmacodynamic …

Infections are an important cause of morbidity and mortality among patients with chronic
kidney disease. Therefore, appropriate antibiotic dosing is imperative to achieve positive …