As large quantities of novel synthetic molecules continue to be generated there is a
challenge to identify therapeutic agents with cytotoxic activity. Here we introduce a …

Nepenthes spp. are carnivorous plants that have developed insect capturing traps, evolved
by specific modification of the leaf tips, and are able to utilize insect degradation products as …

This is the fth volume in the series. To date, four
previous volumes have been both published and well received by the scienti c community …

ISO 10993‐5 provides one of the accepted standards for testing the biotoxicity of new
materials. All of the recommended test procedures rely upon the uptake or metabolism of …

Here, we report that thiol-mediated decomposition of 2, 3-epoxy-1, 4-naphthoquinones to
generate peroxide, a reactive oxygen species (ROS), could be modulated by changing the …

Chagas disease, caused by Trypanosoma cruzi, is a widespread infection in Latin America.
Currently, only 2 partially effective and highly toxic drugs, ie, benznidazole and nifurtimox …

Here, we tested seven 2-acylated-1, 4-hydronaphthoquinones for their cytotoxic effects on a
panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line …

A microwave-assisted solid-supported Dötz benzannulation of chromium carbene
complexes with various alkynes has been developed. The oxidative cleavage of the …

In this brief review, we present recent results in the development of fluorescence-based
assays for the detection of compounds with cytotoxic, anticancer and anti-microbial …

1 H-Benzo [f] indazole-4, 9-dione derivatives conjugated with C-protected amino acids
(glycine, l-alanine, l-phenylalanine and l-glutamic acid) 6a–l were prepared by chemically …