Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

Delirium is the most common manifestation of brain dysfunction in critically ill patients. In the
intensive care unit (ICU), duration of delirium is independently predictive of excess death …

OBJECTIVE: To develop comprehensive clinical practice guidelines for critically ill infants
and children, with specific attention to seven domains of care including pain …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Background Patients who have received mechanical ventilation can have prolonged
cognitive impairment for which there is no known treatment. We aimed to establish whether …

Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management
of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design:

The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of
waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the …

Conventional gabaminergic sedatives such as benzodiazepines and propofol are commonly
used in mechanically ventilated patients in the intensive care unit (ICU). Dexmedetomidine …

Dexmedetomidine is an α 2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic,
and analgesic-sparing effects, and minimal depression of respiratory function. It is potent …

With more than 4 million intensive care unit (ICU) admissions per year in the United States,
there is increasing recognition of the long-term consequences of ICU care on the physical …