Respiratory syncytial virus entry and how to block it

MB Battles, JS McLellan - Nature Reviews Microbiology, 2019 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in
young children and elderly people. Although the virus was isolated in 1955, an effective …

Fusion of enveloped viruses in endosomes

JM White, GR Whittaker - Traffic, 2016 - Wiley Online Library
Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …

Common features of enveloped viruses and implications for immunogen design for next-generation vaccines

FA Rey, SM Lok - Cell, 2018 - cell.com
Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process
catalyzed by a specialized membrane-fusion protein expressed on their surface. This review …

Virus entry: looking back and moving forward

A Helenius - Journal of molecular biology, 2018 - Elsevier
Research over a period of more than half a century has provided a reasonably accurate
picture of mechanisms involved in animal virus entry into their host cells. Successive steps in …

Zoonotic potential of emerging paramyxoviruses: knowns and unknowns

PA Thibault, RE Watkinson, A Moreira-Soto… - Advances in virus …, 2017 - Elsevier
The risk of spillover of enzootic paramyxoviruses and the susceptibility of recipient human
and domestic animal populations are defined by a broad collection of ecological and …

Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

TC Marcink, G Zipursky, W Cheng, K Stearns… - Science …, 2023 - science.org
Paramyxoviruses—including important pathogens like parainfluenza, measles, and Nipah
viruses—use a receptor binding protein [hemagglutinin-neuraminidase (HN) for …

Measles virus fusion protein: structure, function and inhibition

P Plattet, L Alves, M Herren, HC Aguilar - Viruses, 2016 - mdpi.com
Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes
measles in humans. The Paramyxoviridae family of negative single-stranded enveloped …

Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies

NV Johnson, RC van Scherpenzeel… - Nature …, 2024 - nature.com
Respirovirus 3 is a leading cause of severe acute respiratory infections in vulnerable human
populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion …

Structures of Langya virus fusion protein ectodomain in pre-and postfusion conformation

AJ May, KR Pothula, K Janowska, P Acharya - Journal of virology, 2023 - Am Soc Microbiol
Langya virus (LayV) is a paramyxovirus in the Henipavirus genus, closely related to the
deadly Nipah (NiV) and Hendra (HeV) viruses, that was identified in August 2022 through …

Potent henipavirus neutralization by antibodies recognizing diverse sites on Hendra and Nipah virus receptor binding protein

J Dong, RW Cross, MP Doyle, N Kose, JJ Mousa… - Cell, 2020 - cell.com
Summary Hendra (HeV) and Nipah (NiV) viruses are emerging zoonotic pathogens in the
Henipavirus genus causing outbreaks of disease with very high case fatality rates. Here, we …