Simple Summary Significant gender disparities have been highlighted in the incidence,
aggressiveness, and prognosis of HCC. A different epidemiological distribution of the risk …

Abstract Uncoupling protein 1 (UCP1) has been discovered as a possible target for obesity
treatment because of its widespread distribution in the inner mitochondrial membrane of …

Obesity and type 2 diabetes mellitus (T2DM) are chronic pathologies with a high incidence
worldwide. They share some pathological mechanisms, including hyperinsulinemia, the …

The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …

Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence
and mortality rates in men compared to women, potentially due to the effects of estrogen …

Sex differences have been reported for diseases of the musculoskeletal system (MSK) as
well as the risk for injuries to tissues of the MSK system. For females, some of these occur …

Sulfation and desulfation of steroids are opposing processes that regulate the activation,
metabolism, excretion, and storage of steroids, which account for steroid homeostasis …

Estrogen receptor alpha (ERα) is widely expressed in reproductive organs, but also in non-
reproductive tissues of females and males. There is evidence that lipocalin 2 (LCN2), which …

The estrogen receptor beta (ERβ) is physiologically essential for reproductive biology and is
implicated in various diseases. However, despite more than 20 years of intensive research …

Introduction Estrogens are crucial regulators of ovarian function, mediating their signaling
through binding to estrogen receptors. The disruption of the estrogen receptor 1 (Esr1) …