Living organisms are made of wet, soft tissues. However, there is only one candidate to
simultaneously replicate the mechanical and composition features of load-bearing tissues …

Over the last decade, water-soluble polyisocyanopeptides (PICs) have emerged as a new
class of biomimetic polymers. Analogous to biopolymers, PICs exhibit a semi-flexible nature; …

Biomacromolecules based injectable and self-healing hydrogels possessing high
mechanical properties have widespread potential in biomedical field. However, dynamic …

Mechanoresponsiveness is a ubiquitous feature of soft materials in nature; biological tissues
exhibit both strain-stiffening and self-healing in order to prevent and repair deformation …

The fibrous network of an extracellular matrix (ECM) possesses mechanical properties that
convey critical biological functions in cell mechanotransduction. Engineered fibrous …

The bottom-up engineering of artificial cells requires a reconfigurable cytoskeleton that can
organize at distinct locations and dynamically modulate its structural and mechanical …

Fibrosis is characterized by the formation of fibrous connective tissue in response to primary
injury. As a result, an affected organ may lose part of its functionality due to chronic, organ …

Mechanical stimuli such as strain, force, and pressure are pervasive within and beyond the
human body. Mechanoresponsive hydrogels have been engineered to undergo changes in …

Fiber networks are the primary structural components of many biological structures,
including the cell cytoskeleton and the extracellular matrix. These materials exhibit global …

Systemic sclerosis (SSc) is a rare autoimmune disease with limited treatment options that is
characterized by fibrosis in various organs. To screen the effectiveness of new therapies …