Challenges in detecting and quantifying intron retention from next generation sequencing data
L Broseus, W Ritchie - Computational and structural biotechnology journal, 2020 - Elsevier
Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the
final mRNA. An increasing body of literature has demonstrated a major role for IR in …
final mRNA. An increasing body of literature has demonstrated a major role for IR in …
[HTML][HTML] Alternative RNA splicing in stem cells and cancer stem cells: importance of transcript-based expression analysis
Alternative ribonucleic acid (RNA) splicing can lead to the assembly of different protein
isoforms with distinctive functions. The outcome of alternative splicing (AS) can result in a …
isoforms with distinctive functions. The outcome of alternative splicing (AS) can result in a …
[HTML][HTML] Unraveling novel survivin mRNA transcripts in cancer cells using an in-house developed targeted high-throughput sequencing approach
The human baculoviral IAP repeat containing 5 (BIRC5), also known as survivin, is a
conserved member of the inhibitor of apoptosis protein (IAPs) family, which is normally …
conserved member of the inhibitor of apoptosis protein (IAPs) family, which is normally …
Next-generation sequencing reveals alternative L-DOPA decarboxylase (DDC) splice variants bearing novel exons, in human hepatocellular and lung cancer cells
The human L-DOPA decarboxylase (DDC) is an enzyme that displays a pivotal role in
metabolic processes. It is implicated in various human disorders, including hepatocellular …
metabolic processes. It is implicated in various human disorders, including hepatocellular …
Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression
PI Artemaki, M Papatsirou, MA Boti… - International Journal of …, 2020 - mdpi.com
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality
rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the …
rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the …
Knowledge mapping of alternative splicing of cancer from 2012 to 2021: A bibliometric analysis
B Tian, Y Bian, DJ Bian, Y Gao, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Background As a processing method of RNA precursors, alternative splicing (AS) is critical
to normal cellular activities. Aberrant AS events are associated with cancer development …
to normal cellular activities. Aberrant AS events are associated with cancer development …
Identification of novel alternative splice variants of the human L-DOPA decarboxylase (DDC) gene in human cancer cells, using high-throughput sequencing …
The human L-DOPA decarboxylase (DDC) is a gene that has been in the center of research
attention in many laboratories the last decades, due to its major implication in various …
attention in many laboratories the last decades, due to its major implication in various …
Discovery and Comprehensive Characterization of Novel Circular RNAs of the Apoptosis-Related BOK Gene in Human Ovarian and Prostate Cancer Cells, Using …
CircRNAs have become a novel scientific research hotspot, and an increasing number of
studies have shed light on their involvement in malignant progression. Prompted by the …
studies have shed light on their involvement in malignant progression. Prompted by the …
New insights into the dynamics of m6A epitranscriptome: hybrid-seq identifies novel mRNAs of the m6A writers METTL3/14
Background: N6-methyladenosine (m6A), a prevalent mRNA modification, is dynamically
regulated by methyltransferases, including METTL3 and METTL14. Materials & methods: In …
regulated by methyltransferases, including METTL3 and METTL14. Materials & methods: In …
Unraveling novel mRNA transcripts of the human DNA N-glycosylase 1 (NTHL1) gene with the implementation of an innovative targeted DNA-seq assay
The human NTHL1 gene encodes a DNA glycosylase that plays a key role in the base
excision repair (BER) pathway, repairing oxidative DNA damage and maintaining genome …
excision repair (BER) pathway, repairing oxidative DNA damage and maintaining genome …