Combinatorial chemistry and high-throughput screening have increased the possibility of
ˆnding new lead compounds at much shorter time periods than conventional medicinal …

The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …

The human CYP2A gene subfamily consists of three members, CYP2A6, CYP2A7, and
CYP2A13. The CYP2A6 gene is highly polymorphic with approximately 40 annotated allelic …

A new member of the cytochrome P450 superfamily, CYP2S1, has recently been identified
in human and mouse. In this paper, we review the data currently available for CYP2S1. The …

The use of cytochrome P450 (P450 or CYP) enzymes as biocatalysts for the production of
fine chemicals, including pharmaceuticals, has been of increasing interest, primarily owing …

There is an urgent requirement within the pharmaceutical and biotechnology industries,
regulatory authorities and academia to improve the success of molecules that are selected …

Computational chemistry software for lead discovery has become well established in
pharmaceutical industry and has found its way to the desktop computers of medicinal …

The mouse hepatic cytochrome P450 (CYP) 2A5 and its human orthologue CYP2A6
catalyse the metabolism of a number of drugs and toxins, such as halothane and aflatoxin …

Human P450 2A13 is the most efficient enzyme for catalyzing the metabolism of nicotine and
metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). It is …

Cigarette smoking is the primary cause of numerous preventable diseases; as such, the
goals of smoking cessation are both to reduce health risks and to improve the quality of life …