Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

The ability of cells to sense and respond to mechanical signals is vital in development and
healthy tissue functioning. Many diseases are related to either changing mechanical …

Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …