Role of heat shock proteins (HSP70 and HSP90) in viral infection

A Lubkowska, W Pluta, A Strońska, A Lalko - International Journal of …, 2021 - mdpi.com
Heat shock proteins (HSPs) are a large group of chaperones found in most eukaryotes and
bacteria. They are responsible for the correct protein folding, protection of the cell against …

Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development

Q Wan, D Song, H Li, M He - Signal transduction and targeted therapy, 2020 - nature.com
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

Hsp90 regulates GCRV-II proliferation by interacting with VP35 as its receptor and chaperone

L Jiang, A Liu, C Zhang, YA Zhang, J Tu - Journal of Virology, 2022 - Am Soc Microbiol
The frequent outbreak of grass carp hemorrhagic disease caused by grass carp reovirus
(GCRV), especially the mainly prevalent type II GCRV (GCRV-II), has seriously affected the …

HSP90AB1 is a host factor that promotes porcine deltacoronavirus replication

Y Zhao, J Yuan, D Xiao, L Zhang, C Li, J Hu… - Journal of Biological …, 2024 - ASBMB
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus. It causes
mortality in neonatal piglets and is of growing concern because of its broad host range …

Host cell stress response as a predictor of COVID-19 infectivity and disease progression

C Caillet, ML Stofberg, V Muleya, A Shonhai… - Frontiers in Molecular …, 2022 - frontiersin.org
The coronavirus disease (COVID-19) caused by a coronavirus identified in December 2019
has caused a global pandemic. COVID-19 was declared a pandemic in March 2020 and has …

Inhibition of heat shock protein 90 suppresses Bombyx mori nucleopolyhedrovirus replication in B. mori

Q Shang, P Wu, HL Huang, SL Zhang… - Insect molecular …, 2020 - Wiley Online Library
Abstract Heat shock protein 90 (Hsp90) plays a very important role in facilitating the
replication of many viruses. Until now, little has been known about the role of Hsp90 in …

HSP90AB1 is a host factor required for transmissible gastroenteritis virus infection

D Song, Y Zhao, Y Sun, Y Liang, R Chen… - International Journal of …, 2023 - mdpi.com
Transmissible gastroenteritis virus (TGEV) is an important swine enteric coronavirus causing
viral diarrhea in pigs of all ages. Currently, the development of antiviral agents targeting host …

Transcriptome analysis reveals temperature-dependent early immune response in flounder (Paralichthys olivaceus) after Hirame novirhabdovirus (HIRRV) infection

H Wang, X Tang, X Sheng, J Xing, H Chi… - Fish & Shellfish …, 2020 - Elsevier
Hirame novirhabdovirus (HIRRV), as a highly pathogenic fish virus, is frequently prevalent in
a variety of aquaculture fish in recent years, which seriously threatens the healthy …

Hsp90, a team player in protein quality control and the stress response in bacteria

AC Wickramaratne, S Wickner… - … and Molecular Biology …, 2024 - Am Soc Microbiol
SUMMARY Heat shock protein 90 (Hsp90) participates in proteostasis by facilitating protein
folding, activation, disaggregation, prevention of aggregation, degradation, and protection …

Anti-influenza virus activity of benzo [d] thiazoles that target heat shock protein 90

A Lamut, M Gjorgjieva, L Naesens, S Liekens… - Bioorganic …, 2020 - Elsevier
Seasonal or pandemic influenza virus infections are a worldwide health problem requiring
antiviral therapy. Since virus resistance to the established neuraminidase inhibitors and …