Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene
products, reverse the modification of proteins by a single ubiquitin (-like) protein, and …

Stability and localization of p53 is essential for its tumor suppressor function. Ubiquitination
by the E3 ubiquitin ligase Mdm2 is the major regulatory mechanism of p53, which induces …

Loss of p53 function occurs during the development of most, if not all, tumour types. This
paves the way for genomic instability, tumour-associated changes in metabolism …

Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish
asymptomatic life-long persistence. It is associated with a large spectrum of diseases …

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle
apparatus. Centrosomes themselves duplicate once per cell cycle, in a process that is …

The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …

Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally
associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly …