Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Updated review of advances in microRNAs and complex diseases: taxonomy, trends and challenges of computational models

L Huang, L Zhang, X Chen - Briefings in Bioinformatics, 2022 - academic.oup.com
Since the problem proposed in late 2000s, microRNA–disease association (MDA)
predictions have been implemented based on the data fusion paradigm. Integrating diverse …

Controlled synthesis of multicolor carbon dots assisted by machine learning

J Chen, JB Luo, MY Hu, J Zhou… - Advanced Functional …, 2023 - Wiley Online Library
Carbon dots (CDs) have received extensive attention and applications in recent years due to
their remarkable characteristics of tunable emission wavelength, high stability, and a variety …

Customized carbon dots with predictable optical properties synthesized at room temperature guided by machine learning

Q Hong, XY Wang, YT Gao, J Lv, BB Chen… - Chemistry of …, 2022 - ACS Publications
Fluorescent carbon dots (CDs) have been increasingly used in fluorescence detection and
imaging based on their tunable fluorescence (FL) and resistance to photobleaching …

[HTML][HTML] Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder

JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …

[HTML][HTML] A new strategy for the early detection of alzheimer disease stages using multifractal geometry analysis based on K-Nearest Neighbor algorithm

YM Elgammal, MA Zahran, MM Abdelsalam - Scientific reports, 2022 - nature.com
Alzheimer's Disease (AD) is considered one of the most diseases that much prevalent
among elderly people all over the world. AD is an incurable neurodegenerative disease …

[HTML][HTML] Epigenetic biomarkers as diagnostic tools for neurodegenerative disorders

O Martínez-Iglesias, V Naidoo, N Cacabelos… - International Journal of …, 2021 - mdpi.com
Epigenetics is the study of heritable changes in gene expression that occur without
alterations to the DNA sequence, linking the genome to its surroundings. The accumulation …

Analysis of m6A modification regulators in the substantia nigra and striatum of MPTP-induced Parkinson's disease mice

Z Yu, L Huang, Y Xia, S Cheng, C Yang, C Chen… - Neuroscience …, 2022 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative disorders of aging
that impairs predominately dopaminergic neurons. N6-methyladenosine (m6A) is the most …

Advanced electronics and artificial intelligence: Must‐have technologies toward human body digital twins

Y Dai, J Wang, S Gao - Advanced Intelligent Systems, 2022 - Wiley Online Library
The development of precise virtual entities of human bodies has been pursued for many
years, but to date, there have been few positive reports. In recent years, the success of …

[HTML][HTML] Role of TET1-mediated epigenetic modulation in Alzheimer's disease

MJ Armstrong, Y Jin, SM Vattathil, Y Huang… - Neurobiology of …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder influenced by a complex interplay
of environmental, epigenetic, and genetic factors. DNA methylation (5mC) and …