The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

A Emami Nejad, S Najafgholian, A Rostami… - Cancer Cell …, 2021 - Springer
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

TGF-β signaling from receptors to Smads

A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

J Yu, Q Xu, Z Wang, Y Yang, L Zhang, J Ma, S Sun… - Journal of …, 2018 - Elsevier
Background & Aims In recent years, circular RNAs (circRNAs) have been shown to have
critical regulatory roles in cancer biology. However, the contributions of circRNAs to …

Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis

I Fabregat, D Caballero-Díaz - Frontiers in oncology, 2018 - frontiersin.org
The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

TIMPs: versatile extracellular regulators in cancer

HW Jackson, V Defamie, P Waterhouse… - Nature Reviews …, 2017 - nature.com
A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …

The dual role of TGFβ in human cancer: from tumor suppression to cancer metastasis

JJ Lebrun - International Scholarly Research Notices, 2012 - Wiley Online Library
The transforming growth factor‐beta (TGFβ) superfamily encompasses widespread and
evolutionarily conserved polypeptide growth factors that regulate and orchestrate growth …

MicroRNA-181b regulates NF-κB–mediated vascular inflammation

X Sun, B Icli, AK Wara, N Belkin, S He… - The Journal of …, 2012 - Am Soc Clin Investig
EC activation and dysfunction have been linked to a variety of vascular inflammatory
disease states. The function of microRNAs (miRNAs) in vascular EC activation and …

The pervasive role of the miR-181 family in development, neurodegeneration, and cancer

A Indrieri, S Carrella, P Carotenuto, S Banfi… - International journal of …, 2020 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the
regulation of gene expression. Evidence accumulating in the past decades indicate that they …

The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor‐associated macrophages

D Capece, M Fischietti, D Verzella… - BioMed research …, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers
worldwide. HCC is an example of inflammation‐related cancer and represents a paradigm …

Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis

C Lee, J Kim, J Han, D Oh, M Kim, H Jeong… - Nature …, 2022 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is an important health concern worldwide and
progresses into nonalcoholic steatohepatitis (NASH). Although prevalence and severity of …