The steroid hormone receptors (SHRs) are ligand-dependent intracellular transcription
factors that are known to influence the development and growth of many human cancers …

Background The majority of human cancer deaths are caused by metastasis. The metastatic
dissemination is initiated by the breakdown of epithelial cell homeostasis. During this …

Breast cancer initiation, invasion and metastasis span multiple length and time scales.
Molecular events at short length scales lead to an initial tumorigenic population, which left …

The size and complexity of cellular systems make building predictive models an extremely
difficult task. In principle dynamical time-course data can be used to elucidate the structure …

In this study, we developed a dynamic mathematical model of E. coli cell-free protein
synthesis (CFPS). Model parameters were estimated from a dataset consisting of glucose …

These studies compared the efficacies of our clinical agent galeterone (Gal) and the FDA-
approved prostate cancer drug, enzalutamide (ENZ) with two lead next generation …

Background Tumor necrosis factor (TNF) is a widely studied cytokine (ligand) that induces
proinflammatory signaling and regulates myriad cellular processes. In major illnesses, such …

Epithelial to mesenchymal transition (EMT) is an essential differentiation program during
tissue morphogenesis and remodeling. EMT is induced by soluble transforming growth …

A hallmark of severe sepsis is systemic inflammation which activates leukocytes and can
result in their misdirection. This leads to both impaired migration to the locus of infection and …

Computational models represent a highly suitable framework, not only for testing biological
hypotheses and generating new ones but also for optimising experimental strategies. As …