Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C

C Vollbracht, K Kraft - Frontiers in Pharmacology, 2022 - frontiersin.org
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment

RIG Holt, CS Cockram, RCW Ma, AOY Luk - Diabetologia, 2024 - Springer
An association between diabetes and infection has been recognised for many years, with
infection being an important cause of death and morbidity in people with diabetes. The …

[HTML][HTML] Pneumococcal vaccine for adults aged≥ 19 years: recommendations of the Advisory Committee on Immunization Practices, United States, 2023

M Kobayashi - MMWR. Recommendations and Reports, 2023 - cdc.gov
This report compiles and summarizes all published recommendations from CDC's Advisory
Committee on Immunization Practices (ACIP) for use of pneumococcal vaccines in adults …

Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment

RA Keogh, AL Haeberle, CJ Langouët-Astrié… - Science …, 2022 - science.org
Diabetic wounds have poor healing outcomes due to the presence of numerous pathogens
and a dysregulated immune response. Group B Streptococcus (GBS) is commonly isolated …

Neutrophils as emerging protagonists and targets in chronic inflammatory diseases

K Rawat, A Shrivastava - Inflammation Research, 2022 - Springer
Introduction Neutrophils are the key cells of our innate immune system with a primary role in
host defense. They rapidly arrive at the site of infection and display a range of effector …

Mucormycosis in the COVID-19 environment: a multifaceted complication

R Sharma, P Kumar, A Rauf, A Chaudhary… - Frontiers in cellular …, 2022 - frontiersin.org
The second wave of coronavirus disease 2019 (COVID-19) caused severe infections with
high mortality. An increase in the cases of COVID-19-associated mucormycosis (CAM) was …

Group B Streptococcus and diabetes: Finding the sweet spot

RA Keogh, KS Doran - PLoS Pathogens, 2023 - journals.plos.org
Streptococcus agalactiae (Group B Streptococcus, GBS) is a gram-positive pathobiont that
colonizes the gastrointestinal and urogenital tracts of approximately 25% of individuals. GBS …

Neutrophil and macrophage NADPH oxidase 2 differentially control responses to inflammation and to Aspergillus fumigatus in mice

RA Idol, S Bhattacharya, G Huang, Z Song… - The Journal of …, 2022 - journals.aai.org
Aspergillus fumigatus is an important opportunistic fungal pathogen and causes invasive
pulmonary aspergillosis in conditions with compromised innate antifungal immunity …

Mesenchymal stem cell–derived extracellular vesicles as an advanced therapy for chronic wounds

ER Bray, RS Kirsner… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Chronic wounds are a significant challenge for patients, healthcare providers, and
healthcare systems. Chronic wounds develop due to a complex interplay between chronic …

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

MK Thind, HH Uhlig, M Glogauer, N Palaniyar… - Frontiers in …, 2024 - frontiersin.org
Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to
engage a wide range of metabolic pathways for biosynthesis and bioenergetics for …