Mechanisms of DNA damage, repair, and mutagenesis
N Chatterjee, GC Walker - Environmental and molecular …, 2017 - Wiley Online Library
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Translesion DNA polymerases
MF Goodman, R Woodgate - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Living cells are continually exposed to DNA-damaging agents that threaten their genomic
integrity. Although DNA repair processes rapidly target the damaged DNA for repair, some …
integrity. Although DNA repair processes rapidly target the damaged DNA for repair, some …
Advances in understanding the complex mechanisms of DNA interstrand cross-link repair
C Clauson, OD Schärer… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …
Translesion DNA synthesis and mutagenesis in eukaryotes
JE Sale - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The structural features that enable replicative DNA polymerases to synthesize DNA rapidly
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …
Repair of a DNA-protein crosslink by replication-coupled proteolysis
DNA-protein crosslinks (DPCs) are caused by environmental, endogenous, and
chemotherapeutic agents and pose a severe threat to genome stability. We use Xenopus …
chemotherapeutic agents and pose a severe threat to genome stability. We use Xenopus …
DNA–protein cross-links: formation, structural identities, and biological outcomes
NY Tretyakova, A Groehler IV, S Ji - Accounts of chemical …, 2015 - ACS Publications
Conspectus Noncovalent DNA–protein interactions are at the heart of normal cell function. In
eukaryotic cells, genomic DNA is wrapped around histone octamers to allow for …
eukaryotic cells, genomic DNA is wrapped around histone octamers to allow for …
Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis
M Enoiu, J Jiricny, OD Schärer - Nucleic acids research, 2012 - academic.oup.com
DNA interstrand crosslinks (ICLs) formed by antitumor agents, such as cisplatin or mitomycin
C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the …
C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the …
Translesion DNA synthesis polymerases in DNA interstrand crosslink repair
TV Ho, OD Schaerer - Environmental and molecular …, 2010 - Wiley Online Library
DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs
such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents …
such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents …
Radiation-induced DNA–protein cross-links: mechanisms and biological significance
Ionizing radiation produces various DNA lesions such as base damage, DNA single-strand
breaks (SSBs), DNA double-strand breaks (DSBs), and DNA–protein cross-links (DPCs). Of …
breaks (SSBs), DNA double-strand breaks (DSBs), and DNA–protein cross-links (DPCs). Of …