We discuss new approaches to the early detection of keratoconus and recent investigations
regarding the nature of its pathophysiology. We review the current evidence for its complex …

Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal
endothelial dystrophy and the leading indication for corneal transplantation worldwide …

Over the past few years, large investments have been made in genome-wide association
studies (GWAS) with the expectation that some of these studies would lead to the …

The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …

Fuchs endothelial corneal dystrophy (FECD) is a common, familial disease of the corneal
endothelium and is the leading indication for corneal transplantation. Variation in the …

A substantial fraction of glaucoma has a genetic basis. About 5% of primary open angle
glaucoma (POAG) is currently attributed to single-gene or Mendelian forms of glaucoma (ie …

The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional
regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous …

Genetic and environmental components as well as their interaction contribute to the risk of
schizophrenia, making it highly relevant to include environmental factors in genetic studies …

Fuchs endothelial corneal dystrophy (FECD) is a common cause for heritable visual loss in
the elderly. Since the first description of an association between FECD and common …

Common sequence variants have recently joined rare structural polymorphisms as genetic
factors with strong evidence for association with schizophrenia. Here we extend our …