Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

High-mobility group box 1 (HMGB1) is a nuclear factor that is released extracellularly as a
late mediator of lethality in sepsis as well as after necrotic, but not apoptotic, death. Here we …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with
liver surgery under total vascular exclusion or after liver transplantation. The …

The liver can regenerate its volume after major tissue loss. In a mouse model of liver
regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate …

Derangements in apoptosis of liver cells are mechanistically important in the pathogenesis
of end-stage liver disease. Vulnerable hepatocytes can undergo apoptosis via an extrinsic …

Prompt removal of unwanted cells, such as senescent, damaged, genetically mutated, or
virus infected cells, is crucial for the maintenance of liver health. This process is naturally …

Warm and cold hepatic ischemia followed by reperfusion leads to necrotic cell death
(oncosis), which often occurs within minutes of reperfusion. Recent studies also suggest a …

This review highlights recent advances in our understanding of mechanisms underlying
reperfusion injury to the liver after warm hepatic ischemia. Sinusoidal endothelial cells and …