The ability to maintain and differentiate cells in vitro is critical to many advances in the field
of bioengineering. However, on traditional, stiff (E≈ GPa) culture substrates, cells are …

The Hippo pathway is a crucial signaling mechanism that inhibits the growth of cells and
organs during development and in disease. When the Hippo pathway is activated, YAP/TAZ …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

Cells in the body reside within the extracellular matrix (ECM), a three-dimensional
environment that not only provides structural support for the cells, but also influences cellular …

YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How
cells ensure the selective activation of YAP effector genes is unknown. This knowledge is …

Embryonic induction is a key mechanism in development that corresponds to an interaction
between a signalling and a responding tissue, causing a change in the direction of …

Biophysical properties of the cellular microenvironment, including stiffness and geometry,
have been shown to influence cell function. Recent findings have implicated 3D confinement …

The Hippo pathway is a highly conserved signalling pathway that regulates multiple
biological processes, including organ size control and cell fate. Since its discovery, genetic …

Human papillomaviruses (HPV) cause persistent infections by modulating epithelial
homeostasis in cells of the infected basal layer. Using FUCCI and cell-cell competition …