Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …

The urea cycle consists of six consecutive enzymatic reactions that convert waste nitrogen
into urea. Deficiencies of any of these enzymes of the cycle result in urea cycle disorders …

Previous studies have shown that nitric oxide (NO) supplements may prevent bone loss and
fractures in preclinical models of estrogen deficiency. However, the mechanisms by which …

The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic
ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with …

Urea cycle defects (UCDs) are severe inherited metabolic diseases with high unmet needs
which present a permanent risk of hyperammonaemic decompensation and subsequent …

The urea cycle is a liver-based pathway enabling disposal of nitrogen waste. Urea cycle
disorders (UCDs) are inherited metabolic diseases caused by deficiency of enzymes or …

Osteogenesis imperfecta (OI) type V is the second most common form of OI, distinguished by
hyperplastic callus formation and calcification of the interosseous membranes, in addition to …

The increase of blood pressure is accompanied by the changes in the morphology and
function of vascular endothelial cells. Vascular endothelial injury and hypertension actually …

Atherosclerosis is initiated with endothelial cell (EC) dysfunction and vascular inflammation
under hyperlipidemia. Sirtuin 3 (SIRT3) is a mitochondrial deacetylase. However, the …

Nitric oxide (NO) is a critical signaling molecule that has been implicated in the
pathogenesis of neurocognitive diseases. Both excessive and insufficient NO production …