The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …

Segmentation and genome annotation (SAGA) algorithms are widely used to understand
genome activity and gene regulation. These algorithms take as input epigenomic datasets …

The development of the human cerebral cortex is a complex and dynamic process, in which
neural stem cell proliferation, neuronal migration, and post-migratory neuronal organization …

Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene
expression by promoting large-scale transcriptional responses in various cell types and …

Meiotic recombination is an essential mechanism during sexual reproduction and includes
the exchange of chromosome segments between homologous chromosomes. New allelic …

The development of multi-cellular organisms from a single fertilized egg requires to
differentially execute the information encoded in our DNA. This complex process is …

Enhancers represent noncoding regulatory regions of the genome located distantly from
their target genes. They regulate gene expression programs in a context‐specific manner …

Precise control of gene expression is crucial to ensure proper development and biological
functioning of an organism. Enhancers are non-coding DNA elements which play an …

Cohesin loop extrusion facilitates precise gene expression by continuously driving
promoters to sample all enhancers located within the same topologically-associated domain …