Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review

X Li, Y Song - European Journal of Medicinal Chemistry, 2023 - Elsevier
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

Bioactive natural products in COVID-19 therapy

Z Wang, N Wang, L Yang, X Song - Frontiers in Pharmacology, 2022 - frontiersin.org
The devastating COVID-19 pandemic has caused more than six million deaths worldwide
during the last 2 years. Effective therapeutic agents are greatly needed, yet promising magic …

[HTML][HTML] SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

L Liu, J Du, S Yang, B Zheng, J Shen, J Huang, L Cao… - Redox biology, 2023 - Elsevier
Viral infection-induced cell death has long been considered as a double-edged sword in the
inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 …

[HTML][HTML] SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway

RS Hamad, HM Al-Kuraishy, A Alexiou… - Cell Stress and …, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and …

Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects

G Culletta, B Buttari, M Arese, S Brogi… - European journal of …, 2024 - Elsevier
By controlling several antioxidant and detoxifying genes at the transcriptional level,
including NAD (P) H quinone oxidoreductase 1 (NQO1), multidrug resistance-associated …

[HTML][HTML] Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins

G Baron, A Altomare, L Della Vedova, F Gado… - Redox Biology, 2024 - Elsevier
Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE),
are intricate compounds composed of interconnected flavan-3-ol units. Renowned for their …

The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

HM Al‐kuraishy, AI Al‐Gareeb… - … of Biochemical and …, 2024 - Wiley Online Library
COVID‐19 is caused by a novel SARS‐CoV‐2 leading to pulmonary and extra‐pulmonary
manifestations due to oxidative stress (OS) development and hyperinflammation. COVID‐19 …

NRF2-mediated regulation of lipid pathways in viral infection

K Muzammil, ZS Ghnim, IS Gataa… - Molecular Aspects of …, 2024 - Elsevier
The first line of defense against viral infection of the host cell is the cellular lipid membrane,
which is also a crucial first site of contact for viruses. Lipids may sometimes be used as viral …

Synthesis and Characterization of Carbon-Based Quantum Dots and Doped Derivatives for Improved Andrographolide's Hydrophilicity in Drug Delivery Platforms

N Medina-Berríos, W Pantoja-Romero… - ACS …, 2024 - ACS Publications
Carbon-based quantum dots (CBQDs), sulfur-doped carbon-based quantum dots (S-
CBQDs), and nitrogen-doped carbon-based quantum dots (N-CBQDs) have strong potential …

Andrographolide attenuates SARS-CoV-2 infection via an up-regulation of glutamate-cysteine ligase catalytic subunit (GCLC)

J Chaopreecha, N Phueakphud, A Suksatu… - Phytomedicine, 2025 - Elsevier
Background Andrographolide is a medicinal compound which possesses anti-SARS-CoV-2
activity. A number of cellular targets of andrographolide have been identified by target …