Optimal transport for single-cell and spatial omics
High-throughput single-cell profiling provides an unprecedented ability to uncover the
molecular states of millions of cells. These technologies are, however, destructive to cells …
molecular states of millions of cells. These technologies are, however, destructive to cells …
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants
In all multicellular organisms, transcriptional networks orchestrate organ development. The
Arabidopsis root, with its simple structure and indeterminate growth, is an ideal model for …
Arabidopsis root, with its simple structure and indeterminate growth, is an ideal model for …
Evolutionary cell type mapping with single-cell genomics
A Tanay, A Sebé-Pedrós - Trends in genetics, 2021 - cell.com
A fundamental characteristic of animal multicellularity is the spatial coexistence of
functionally specialized cell types that are all encoded by a single genome sequence. Cell …
functionally specialized cell types that are all encoded by a single genome sequence. Cell …
Single-cell RNA sequencing of the Strongylocentrotus purpuratus larva reveals the blueprint of major cell types and nervous system of a non-chordate deuterostome
Identifying the molecular fingerprint of organismal cell types is key for understanding their
function and evolution. Here, we use single-cell RNA sequencing (scRNA-seq) to survey the …
function and evolution. Here, we use single-cell RNA sequencing (scRNA-seq) to survey the …
[HTML][HTML] Plastic leachate-induced toxicity during sea urchin embryonic development: Insights into the molecular pathways affected by PVC
Microplastics are now polluting all seas and, while studies have found numerous negative
interactions between plastic pollution and marine animals, the effects on embryonic …
interactions between plastic pollution and marine animals, the effects on embryonic …
ROCK and the actomyosin network control biomineral growth and morphology during sea urchin skeletogenesis
E Hijaze, T Gildor, R Seidel, M Layous, M Winter… - Elife, 2024 - elifesciences.org
Biomineralization had apparently evolved independently in different phyla, using distinct
minerals, organic scaffolds, and gene regulatory networks (GRNs). However, diverse …
minerals, organic scaffolds, and gene regulatory networks (GRNs). However, diverse …
Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins
Abstract Changes in developmental gene regulatory networks (dGRNs) underlie much of the
diversity of life, but the evolutionary mechanisms that operate on regulatory interactions …
diversity of life, but the evolutionary mechanisms that operate on regulatory interactions …
Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories
Y Dai, Y Zhong, R Pan, L Yuan, Y Fu, Y Chen… - Nature Ecology & …, 2024 - nature.com
The common ancestor of all vertebrates had a highly sophisticated nervous system, but
questions remain about the evolution of vertebrate neural cell types. The amphioxus, a …
questions remain about the evolution of vertebrate neural cell types. The amphioxus, a …
Reconstruction of single-cell lineage trajectories and identification of diversity in fates during the epithelial-to-mesenchymal transition
Exploring the complexity of the epithelial-to-mesenchymal transition (EMT) unveils a
diversity of potential cell fates; however, the exact timing and mechanisms by which early …
diversity of potential cell fates; however, the exact timing and mechanisms by which early …
New hypotheses of cell type diversity and novelty from orthology-driven comparative single cell and nuclei transcriptomics in echinoderms
Cell types are the building blocks of metazoan biodiversity and offer a powerful perspective
for inferring evolutionary phenomena. With the development of single-cell transcriptomic …
for inferring evolutionary phenomena. With the development of single-cell transcriptomic …