Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Runx2 is an essential transcription factor for skeletal development. It is expressed in
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …

Decades of work have identified the signaling pathways that regulate the differentiation of
chondrocytes during bone formation, from their initial induction from mesenchymal …

Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx),
that is specifically expressed in all developing bones. In Osx null mice, no bone formation …

Vertebrates do not look like jellyfish because the bones of their skeletons are levers that
allow movement and protect vital organs. Bones come in an enormous variety of shapes and …

The skeleton is an efficient'servo'(feedback-controlled/steady-state) system that continuously
integrates signals and responses which sustain its functions of delivering calcium while …

RUNX2 is a multifunctional transcription factor that controls skeletal development by
regulating the differentiation of chondrocytes and osteoblasts and the expression of many …