[HTML][HTML] Mitochondrial channels: ion fluxes and more

I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

KATP Channels in the Cardiovascular System

MN Foster, WA Coetzee - Physiological reviews, 2016 - journals.physiology.org
KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

[HTML][HTML] What do we not know about mitochondrial potassium channels?

M Laskowski, B Augustynek, B Kulawiak… - … et Biophysica Acta (BBA …, 2016 - Elsevier
In this review, we summarize our knowledge about mitochondrial potassium channels, with
a special focus on unanswered questions in this field. The following potassium channels …

Mitochondrial potassium channels as druggable targets

A Wrzosek, B Augustynek, M Żochowska, A Szewczyk - Biomolecules, 2020 - mdpi.com
Mitochondrial potassium channels have been described as important factors in cell pro-life
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …

Role of posttranslational modifications of proteins in cardiovascular disease

YP Liu, TN Zhang, R Wen, CF Liu… - Oxidative Medicine and …, 2022 - Wiley Online Library
Cardiovascular disease (CVD) has become a leading cause of mortality and morbidity
globally, making it an urgent concern. Although some studies have been performed on CVD …

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

RR Nazarewicz, AE Dikalova… - American Journal …, 2013 - journals.physiology.org
Superoxide (O2·−) production by the NADPH oxidases is implicated in the pathogenesis of
many cardiovascular diseases, including hypertension. We have previously shown that …

Multiplicity of effectors of the cardioprotective agent, diazoxide

WA Coetzee - Pharmacology & therapeutics, 2013 - Elsevier
Diazoxide has been identified over the past 50 years to have a number of physiological
effects, including lowering the blood pressure and rectifying hypoglycemia. Today it is used …

KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury

LN Maslov, SV Popov, NV Naryzhnaya… - Fundamental & …, 2023 - Wiley Online Library
Background The use of percutaneous coronary intervention (PCI) in patients with ST‐
segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5 …

LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21

XH Zhou, HX Chai, M Bai, Z Zhang - Cell Cycle, 2020 - Taylor & Francis
The present study was designed to investigate whether and how lncRNA-GAS5 regulates
cardiomyocyte apoptosis in MI. MI rat model was established by the left anterior descending …

Protein kinase C as a stress sensor

ME Barnett, DK Madgwick, DJ Takemoto - Cellular signalling, 2007 - Elsevier
While there are many reviews which examine the group of proteins known as protein kinase
C (PKC), the focus of this article is to examine the cellular roles of two PKCs that are …