The sigma-1 receptor as a pluripotent modulator in living systems
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
Repurposing sigma-1 receptor ligands for COVID-19 therapy?
JM Vela - Frontiers in Pharmacology, 2020 - frontiersin.org
Outbreaks of emerging infections, such as COVID-19 pandemic especially, confront health
professionals with the unique challenge of treating patients. With no time to discover new …
professionals with the unique challenge of treating patients. With no time to discover new …
Structures of the σ2 receptor enable docking for bioactive ligand discovery
The σ2 receptor has attracted intense interest in cancer imaging, psychiatric disease,
neuropathic pain,–and other areas of biology,. Here we determined the crystal structure of …
neuropathic pain,–and other areas of biology,. Here we determined the crystal structure of …
Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response
MS Yousuf, JJ Sahn, H Yang… - Proceedings of the …, 2023 - National Acad Sciences
The sigma 2 receptor (σ2R) was described pharmacologically more than three decades ago,
but its molecular identity remained obscure until recently when it was identified as …
but its molecular identity remained obscure until recently when it was identified as …
Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases
The sigma-1 (σ1) receptor, an enigmatic protein originally classified as an opioid receptor
subtype, is now understood to possess unique structural and functional features of its own …
subtype, is now understood to possess unique structural and functional features of its own …
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
M Rodríguez-Muñoz, Y Onetti, E Cortés-Montero… - Molecular brain, 2018 - Springer
Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis
sativa plant, exhibits therapeutic potential for various human diseases, including chronic …
sativa plant, exhibits therapeutic potential for various human diseases, including chronic …
[HTML][HTML] Efficacy of a novel sigma-1 receptor antagonist for oxaliplatin-induced neuropathy: a randomized, double-blind, placebo-controlled phase IIa clinical trial
J Bruna, S Videla, AA Argyriou, R Velasco, J Villoria… - …, 2018 - Elsevier
This trial assessed the efficacy of MR309 (a novel selective sigma-1 receptor ligand
previously developed as E-52862) in ameliorating oxaliplatin-induced peripheral …
previously developed as E-52862) in ameliorating oxaliplatin-induced peripheral …
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
Abstract The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the
mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and …
mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and …
Sigma 1 receptor: a new therapeutic target for pain
Abstract Sigma 1 receptor (σ 1 receptor) is a unique ligand-regulated molecular chaperone
located mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is …
located mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is …
TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
A Marcotti, J Fernández-Trillo, A González… - Brain, 2023 - academic.oup.com
Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of
anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced …
anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced …