Purpose To develop symmetric echo planar imaging (EPI) and a reference scan framework
for hyperpolarized 13C metabolic imaging. Methods Symmetric, ramp‐sampled EPI with …

Based on the expanding set of applications for hyperpolarized carbon‐13 (HP‐13C) MRI,
this work aims to communicate standardized methodology implemented at the University of …

Hyperpolarized carbon-13 magnetic resonance imaging has enabled the real-time
observation of perfusion and metabolism in vivo. These experiments typically aim to …

Purpose Various excitation strategies have been proposed for dynamic imaging of
hyperpolarized agents such as [1‐13C]‐pyruvate, but the impact of these strategies on …

Purpose To determine the feasibility of extracting sufficiently precise estimates of cell radius,
R, and intracellular volume fraction, fi, from DW‐MRI data in order to distinguish between …

We present a method of computing optimal input trajectories for parameter estimation in
nonlinear dynamical systems using dynamic programming. In contrast with previously …

A key parameter of interest recovered from hyperpolarized (HP) MRI measurements is the
apparent pyruvate-to-lactate exchange rate, k PL, for measuring tumor metabolism. This …

We consider the problem of optimal input design for estimating uncertain parameters in a
discrete-time linear state space model, subject to simultaneous amplitude and ℓ 1/ℓ 2-norm …

We present a method of exploiting symmetries of discrete-time optimal control problems to
reduce the dimensionality of dynamic programming iterations. The results are derived for …

Unknown parameters in models of dynamical systems can be learned reliably only when the
system is excited such that the measured output data is informative. Given a statistical model …