Aldol condensation is an important synthetic method widely used in organic synthesis.
Development of catalytic methods that avoids the production of stoichiometric by-products …

[3, 4]-Fused oxindoles are the core structures of the naturally occurring oxindole alkaloids,
and the fused tricyclic structures have distinguished themselves with unique biological …

Paullones are a class of molecules structurally based on the 7, 12-dihydroindolo [3, 2-d][1]
benzazepin-6 (5H)-one parent scaffold. Many of these structures are inhibitors of certain …

Carbocation-initiated cascade [1, 5]-hydride transfer/cyclization and dimerization reactions
were developed to synthesize dihydrodibenzo [b, e] azepine and …

A general method for the formation of fused dihydroazepine derivatives from 1‐sulfonyl‐1, 2,
3‐triazoles bearing a tethered diene is reported. The process involves an intramolecular …

Synthesis of 1-benzazepines has been achieved via a [1, 5]-hydride shift/7-endo cyclization
sequence. The focus of this research is a direct transformation of 2-(aryl) cyclopropane 1, 1 …

Novel and practical acid-catalyzed cyclization of 2-indolyl aryl carbinols via tandem
dehydration/1, 5-hydride shift/7-cyclization sequences has been developed. By appropriate …

Chagas' disease, a parasitic infection widely distributed throughout Latin America, is a major
public health problem with devastating consequences in terms of human morbidity and …

In the field of chemical engineering, mathematical models have been proven to be an
indispensable tool for process analysis, process design, and condition monitoring. To gain …

To develop multikinase inhibitors with dual PLK1/VEGF-R2 inhibitory activity, the d-
annulated 1-benzazepin-2-one scaffold present in the paullone family of kinase inhibitors …