Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …

Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …

Learning has been associated with modifications of synaptic and circuit properties, but the
precise changes storing information in mammals have remained largely unclear. We …

In the hippocampus, spatial maps are formed by place cells while contextual memories are
thought to be encoded as engrams,,,,–. Engrams are typically identified by expression of the …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

Identifying gene-regulatory targets of nuclear proteins in tissues is a challenge. Here we
describe intranuclear cellular indexing of transcriptomes and epitopes (inCITE-seq), a …

Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …

Single-cell RNA-seq and single-cell assay for transposase-accessible chromatin (ATAC-
seq) technologies are used extensively to create cell type atlases for a wide range of …

Memory encodes past experiences, thereby enabling future plans. The basolateral
amygdala is a centre of salience networks that underlie emotional experiences and thus has …

Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular
mechanisms that fulfill established criteria for the physiological correlates of learning and …