Recent advances in continuous-flow organocatalysis for process intensification

C De Risi, O Bortolini, A Brandolese… - Reaction Chemistry & …, 2020 - pubs.rsc.org
Chemistry in continuous-flow continues to attract attention from the community of synthetic
organic chemists due to its now well-recognized benefits including, inter alia, quick reaction …

Role of continuous flow processes in green manufacturing of pharmaceuticals and specialty chemicals

JA Bennett, ZS Campbell, M Abolhasani - Current Opinion in Chemical …, 2019 - Elsevier
Highlights•An overview of the elements of continuous flow processes.•Synopsis of recent
advancements in green continuous manufacturing strategies.•Synopsis of recent …

Integration of segmented microflow chemistry and online HPLC/MS analysis on a microfluidic chip system enabling enantioselective analyses at the nanoliter scale

SK Piendl, T Schönfelder, M Polack, L Weigelt… - Lab on a Chip, 2021 - pubs.rsc.org
In this work, we introduce an approach to merge droplet microfluidics with an HPLC/MS
functionality on a single chip to analyze the contents of individual droplets. This is achieved …

High-throughput and ultrafast liquid chromatography

AS Kaplitz, GA Kresge, B Selover, L Horvat… - Analytical …, 2019 - ACS Publications
Analytical scientists working in many sectors have long expressed the need for increasingly
fast chromatographic separations. The pharmaceutical industry, for example, has a growing …

Multiple heart-cutting two-dimensional chip-HPLC combined with deep-UV fluorescence and mass spectrometric detection

SK Piendl, D Geissler, L Weigelt, D Belder - Analytical chemistry, 2020 - ACS Publications
In this work, we introduce a new two-dimensional chip-based high-performance liquid
chromatography (2D chip-HPLC) approach, which enables multiple transfers from the first …

[HTML][HTML] Spectroscopic microreactors for heterogeneous catalysis

BA Rizkin, FG Popovic, RL Hartman - Journal of Vacuum Science & …, 2019 - pubs.aip.org
Microfluidic reactors with in situ spectroscopy have enabled many new directions of
research over the last two decades. The miniature nature of these systems enables several …

Tungstic acid-functionalized polycalix [4] resorcinarene as a cavity-containing hyper-branched supramolecular and recoverable acidic catalyst in 4 H-pyran synthesis

AM Asl, B Karami, Z Karimi - RSC advances, 2023 - pubs.rsc.org
In this study, tungstic acid immobilized on polycalix [4] resorcinarene, PC4RA@ SiPr–
OWO3H, as a mesoporous acidic solid catalyst was synthesized and investigated for its …

2D in seconds: coupling of chip-HPLC with ion mobility spectrometry

SK Piendl, CR Raddatz, NT Hartner, C Thoben… - Analytical …, 2019 - ACS Publications
The online hyphenation of chip-based high-performance liquid chromatography (chip-
HPLC) with ion mobility spectrometry (IMS) via fully integrated electrospray emitters is …

Expanding the Toolbox of Heterogeneous Asymmetric Organocatalysts: Bifunctional Cyclopropenimine Superbases for Enantioselective Catalysis in Batch and …

C Leonardi, A Brandolese, L Preti… - Advanced Synthesis …, 2021 - Wiley Online Library
A strategy for the immobilization of chiral 2, 3‐bisaminocyclopropenium salt (pre‐catalyst)
onto polystyrene and silica supports is presented together with a suitable procedure for the …

Microwave-assisted multicomponent synthesis of julolidines using silica-supported calix [4] arene as heterogeneous catalyst

WF de Paiva, IB Braga, JV de Assis, SMB Castañeda… - Tetrahedron, 2019 - Elsevier
The application of immobilizing calixarene onto the surface of silica using a sol-gel method,
as an efficient heterogeneous catalyst (CX4SO 3 HSi (n)) for multicomponent Povarov …