Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Many patients with epilepsy do not obtain proper control of their seizures through
conventional treatment. We review aspects of the pathophysiology underlying epileptic …

Epilepsy, one of the most prevalent neurological disorders, affects approximately 1%(greater
than 60 million) of the world's population. In an estimated 20 million of these patients …

Objective Drug‐resistant epilepsy causes great clinical danger and still lacks effective
treatments. Methods Here, we used multifaceted approaches combining electrophysiology …

Low-frequency stimulation (LFS) has been considered as an option for the treatment of
intractable epilepsy. However, previous data showed that LFS of certain brain regions only …

High-frequency stimulation (HFS) of the anterior nucleus of thalamus (ANT) is a new and
alternative option for the treatment of intractable epilepsy. However, the responder rate is …

Background Deep brain stimulation (DBS) has emerged as a potential therapeutic strategy
in the treatment of neurological disorders including epilepsy. However, the cellular …

Low frequency stimulation (LFS) may be considered as a new potential therapy for drug-
resistant epilepsy. However, the relation between LFS parameters and its anticonvulsant …

Neuromodulation with low-frequency stimulation (LFS), of brain structures other than
epileptic foci, is effective in inhibiting seizures in animals and patients, whereas selection of …

The closed-loop electrical stimulation is emerging as a promising neural modulation therapy
for refractory epilepsy. However, the efficacy of electrical stimulation is less than optimal and …