Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

Transposable elements (TEs) are essential components of eukaryotic genomes and are
subject to stringent regulatory mechanisms to avoid their potentially deleterious effects …

Abstract Toll-like receptor (TLR) 4 contributes to be the induction of neuroinflammation by
recognizing pathology-associated ligands and activating microglia. In addition, numerous …

Takahashi et al. 1 recently concluded that the retrotransposon LINE-1 (L1) drives
neurodegeneration in ataxia telangiectasia (AT). They reported increased cerebellar L1 …

Previous studies have shown the essential roles of O-GlcNAc transferase (Ogt) and O-
GlcNAcylation in neuronal development, function and neurologic diseases. However, the …

Loss of the ATM protein kinase in humans results in Ataxia-telangiectasia, a disorder
characterized by childhood-onset neurodegeneration of the cerebellum as well as cancer …

Improvements in functional genomic annotation have led to a critical mass of neurogenetic
discoveries. This is exemplified in hereditary ataxia, a heterogeneous group of disorders …

Retrotransposable elements (RTEs) are common mobile genetic elements comprising∼
42% of the human genome. RTEs play critical roles in gene regulation and function, but how …

The POGZ gene has been found frequently mutated in neurodevelopmental disorders
(NDDs) such as autism spectrum disorder (ASD) and intellectual disability (ID). We have …

Abnormal activity of LINE-1 transposable elements has been associated with neurological
disease. In this issue of Neuron, Takahashi et al.(2022) show that L1 hyperactivity occurs in …