Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that encompasses a
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …

Up to 99% of systemically administered nanoparticles are cleared through the liver. Within
the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells) …

BACKGROUND & AIMS: Capillarization, characterized by loss of differentiation of liver
sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated …

Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …

The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …

LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

To maintain homeostasis, the animal body is equipped with a powerful system to remove
circulating waste. This review presents evidence that the scavenger endothelial cell (SEC) is …

Oxygen is vital for life as it is required for many different enzymatic reactions involved in
intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption …