Schild, Detlev, and Diego Restrepo. Transduction Mechanisms in Vertebrate Olfactory
Receptor Cells. Physiol. Rev. 78: 429–466, 1998.—Considerable progress has been made …

The inhibitory neurotransmitter GABA acts in the mammalian brain through two different
receptor classes: GABAA and GABAB receptors. GABAB receptors differ fundamentally from …

Channelrhodopsins (ChRs) are used to optogenetically depolarize neurons. We engineered
a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with …

The somatic voltage clamp technique has revolutionized understanding of synaptic
physiology and the excitability of neurons. Although computer simulations have indicated …

This review examines dopamine (DA) and glutamate receptor interactions in the neostriatum
(NS) primarily from a neurophysiological perspective. Historically, a clear understanding of …

Cepeda, Carlos, Christopher S. Colwell, Jason N. Itri, Scott H. Chandler, and Michael S.
Levine. Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal …

The mechanisms responsible for seizure generation in cortical dysplasia (CD) are unknown,
but morphologically abnormal cells could contribute. We examined the passive and active …

Synapses are the fundamental units of information processing in the mammalian brain.
Much of our understanding of their functional properties comes from voltage-clamp analysis …

All cells maintain ionic gradients across their plasma membranes, producing
transmembrane potentials (Vmem). Mounting evidence suggests a relationship between …

Recent evidence indicates that ionic selectivity in voltage-gated Na+ channels is mediated
by a small number of residues in P-region segments that link transmembrane elements S5 …