Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

The plasma membrane sodium-potassium pumps that regulate intracellular sodium in most
animal cells have specific, high-affinity receptors for the digitalis glycosides and their …

This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

The search for endogenous digitalis has led to the isolation of ouabain as well as several
additional cardiotonic steroids of the cardenolide and bufadienolide type from blood …

Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

Bayer red mud (RM) occupies a large amount of land, which excessive Na+ seriously
damages groundwater resources. In this research, a RM based cementitious material (RMC) …

The Na, K-ATPase is the membrane “pump” that generates the Na+ and K+ gradients across
the plasma membrane that drives many physiological processes. This enzyme is highly …

Na+, K+-ATPase is ubiquitously expressed in the plasma membrane ofall animal cells
where it serves as the principal regulator of intracellularion homeostasis. Na+, K+-ATPase is …

Cardiac glycosides have been used for decades to treat congestive heart failure. The recent
identification of cardiotonic steroids such as ouabain, digoxin, marinobufagenin, and …

Examination of 180 patients with cutaneous malignant melanoma and 197 control patients
in a case-control study showed that the risk of melanoma is strongly related to numbers of …