Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling

L Zhao, HL Ciallella, LM Aleksunes, H Zhu - Drug discovery today, 2020 - Elsevier
Highlights•Drug discovery has been advanced to a big data era with a large amount of
public data sources available.•Ten V features (volume, velocity, variety, veracity, validity …

Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world

JM Hagel, PJ Facchini - Plant and Cell Physiology, 2013 - academic.oup.com
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites with a long history of investigation. Although the ecophysiological functions of …

Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives

H Rasouli, R Yarani, F Pociot… - Pharmacological …, 2020 - Elsevier
Diabetes mellitus (DM) is a chronic metabolic disease which causes millions of death all
over the world each year, and its incidence is on increase. The most prevalent form, type 2 …

The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus

BW Obiang-Obounou, OH Kang, JG Choi… - The Journal of …, 2011 - jstage.jst.go.jp
Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria
canadensis. It is known to perform a wide spectrum of biological activities. The aim of this …

Supercritical fluid chromatography in traditional Chinese medicine analysis

Y Huang, G Tang, T Zhang, M Fillet, J Crommen… - … of Pharmaceutical and …, 2018 - Elsevier
Abstracts Traditional Chinese medicines (TCMs) are gaining increasing popularity
throughout the world due to their long historical clinical practices. Highly efficient analytical …

Microbial factories for the production of benzylisoquinoline alkaloids

L Narcross, E Fossati, L Bourgeois, JE Dueber… - Trends in …, 2016 - cell.com
Benzylisoquinoline alkaloids (BIAs) are a family of∼ 2500 alkaloids with both potential and
realized pharmaceutical value, including most notably the opiates such as codeine and …

Comprehensive Tools of Alkaloid/Volatile Compounds–Metabolomics and DNA Profiles: Bioassay-Role-Guided Differentiation Process of Six Annona sp. Grown in …

MA Mohammed, N Elzefzafy, MF El-Khadragy… - Pharmaceuticals, 2024 - mdpi.com
Trees of the Annona species that grow in the tropics and subtropics contain compounds that
are highly valuable for pharmacological research and medication development and have …

Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana

KB Pandeya, A Ganeshpurkar, MK Mishra - Medical Hypotheses, 2020 - Elsevier
COVID-19 has become disastrous for world and spread all over. Researchers all around the
globe are working to discover a drug to cure from COVID-19. RNA dependent RNA …

Computational strategies for the discovery of biological functions of health foods, nutraceuticals and cosmeceuticals: a review

LE Carpio, Y Sanz, R Gozalbes, SJ Barigye - Molecular diversity, 2021 - Springer
Scientific and consumer interest in healthy foods (also known as functional foods),
nutraceuticals and cosmeceuticals has increased in the recent years, leading to an …

Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models

MJ Uddin, ASM Ali Reza… - Frontiers in …, 2018 - frontiersin.org
Anisomeles indica (L.) kuntze is widely used in folk medicine against various disorders
including allergy, sores, inflammation, and fever. This research investigated the …