[HTML][HTML] Mechanism of action of the bile acid receptor TGR5 in obesity
W Lun, Q Yan, X Guo, M Zhou, Y Bai, J He… - … Pharmaceutica Sinica B, 2024 - Elsevier
G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and
Takeda G protein-coupled receptor 5 (TGR5) is a member of this family. As a membrane …
Takeda G protein-coupled receptor 5 (TGR5) is a member of this family. As a membrane …
Bioactive signalling lipids as drivers of chronic liver diseases
Lipids are important in multiple cellular functions, with most having structural or energy
storage roles. However, a small fraction of lipids exert bioactive roles through binding to G …
storage roles. However, a small fraction of lipids exert bioactive roles through binding to G …
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
JS Fleishman, S Kumar - Signal Transduction and Targeted Therapy, 2024 - nature.com
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders
The farnesoid-x-receptor (FXR) and the G protein bile acid activated receptor (GPBAR) 1 are
two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and …
two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and …
Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in …
Conclusions: By genetic and pharmacological approaches, we demonstrated that GPBAR1
and CYSLTR1 mutually interact in the development of DILI. A combinatorial approach …
and CYSLTR1 mutually interact in the development of DILI. A combinatorial approach …
[PDF][PDF] Research Progress of Multi-Target Drugs in the Treatment of Non-Alcoholic Steatohepatitis
W Cheng, C Chen, X Tan - International Journal of Frontiers in …, 2022 - francis-press.com
Non-alcoholic steatohepatitis is a clinical syndrome with pathological changes similar to
alcoholic steatohepatitis without a history of excessive alcohol consumption, and is a key …
alcoholic steatohepatitis without a history of excessive alcohol consumption, and is a key …