Graphical approaches allow one to map the relative importance of different objectives as
well as their relation onto an appropriately tailored multiple comparison procedure. They …

Clinical trials in the era of precision medicine require assessment of biomarkers to identify
appropriate subgroups of patients for targeted therapy. In a biomarker‐stratified design …

Commonly used designs for clinical trials involving biomarkers include targeted design,
biomarker‐stratified design (BSD), and biomarker‐guided (strategy) design (BGD). This …

Adaptive designs are increasingly adopted to make the process of drug development more
efficient. In particular, seamless phase II/III clinical trials allow interim adaptations such as …