Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and
inflammatory bowel disease. Toxicity from use is associated with severe morbidity and …

Methotrexate (MTX) is a folate analog widely used against a range of diseases including
malignancies and autoimmune disorders. Its high effectiveness‐price ratio also won …

Background Leucovorin (folinic acid) is a commonly used antidote for severe toxicity with
low-dose methotrexate, but its optimum dose is unclear, varying from 15 to 25 mg every 6-h …

Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disease caused by a
malfunction of the immune system. The aim of this study was to examine the anti-arthritic …

Objective To study whether organic anion transporter 3 (OAT3) is involved in the
development of methotrexate (MTX) resistance in the treatment of rheumatoid arthritis …

Aims To study the predictive factors for the development of clinical manifestations in
poisoning due to the erroneous taking of low‐dose methotrexate (MTX). Methods A …

Aim There is a deficiency in the data concerning the clinical forms of methotrexate‐induced
oral ulcers. This study was conducted to stratify clinical forms of methotrexate‐induced oral …

Objective To explore the efficacy and safety of combination therapy with methotrexate (MTX)
plus hydroxychloroquine (HCQ) vs. MTX monotherapy in patients with rheumatoid arthritis …

Background and Objectives: Biological therapy is widely used for the treatment of severe
psoriasis. The objective of this study was to evaluate the efficacy and safety of biological …

This case study studies the adverse effects of methotrexate toxicity as well as the importance
of early recognition of the symptoms and signs of methotrexate toxicity. This study involves a …