Biocomputing based on DNA strand displacement reactions

H Lv, Q Li, J Shi, C Fan, F Wang - ChemPhysChem, 2021 - Wiley Online Library
The high sequence specificity and precise base complementary pairing principle of DNA
provides a rich orthogonal molecular library for molecular programming, making it one of the …

Biotemplated precise assembly approach toward ultra-scaled high-performance electronics

Y Chen, M Zhao, Y Ouyang, S Zhang, Z Liu, K Wang… - Nature …, 2023 - nature.com
Structural DNA nanotechnology can be programmed into complex designer structures with
molecular precision for directing a wide range of inorganic and biological materials …

A DNAzyme-amplified DNA circuit for highly accurate microRNA detection and intracellular imaging

H Wang, H Wang, Q Wu, M Liang, X Liu, F Wang - Chemical Science, 2019 - pubs.rsc.org
Biomolecular self-assembly circuits have been well developed for high-performance
biosensing and bioengineering applications. Here we designed an isothermal concatenated …

Engineering DNA nanostructures for siRNA delivery in plants

H Zhang, H Zhang, GS Demirer, E González-Grandío… - Nature protocols, 2020 - nature.com
Targeted downregulation of select endogenous plant genes is known to confer disease or
pest resistance in crops and is routinely accomplished via transgenic modification of plants …

DNA Tile Self‐Assembly Guided by Base Excision Repair Enzymes

N Farag, G Ercolani, E Del Grosso… - Angewandte Chemie, 2022 - Wiley Online Library
We demonstrate here the use of DNA repair enzymes to control the assembly of DNA‐based
structures. To do so, we employed uracil‐DNA glycosylase (UDG) and formamidopyrimidine …

Paclitaxel-promoted supramolecular polymerization of peptide conjugates

H Su, W Zhang, H Wang, F Wang… - Journal of the American …, 2019 - ACS Publications
Spontaneous association above a threshold concentration is a hallmark of supramolecular
polymerization, in which monomeric units self-assemble into polymeric aggregates through …

Encoding quantized fluorescence states with fractal DNA frameworks

J Li, J Dai, S Jiang, M Xie, T Zhai, L Guo, S Cao… - Nature …, 2020 - nature.com
Signal amplification in biological systems is achieved by cooperatively recruiting multiple
copies of regulatory biomolecules. Nevertheless, the multiplexing capability of artificial …

A DNA tetrahedral structure-mediated ultrasensitive fluorescent microarray platform for nucleic acid test

H Zhang, X Liu, C Zhang, Y Xu, J Su, X Lu, J Shi… - Sensors and Actuators B …, 2020 - Elsevier
Microarrays are key platforms for biomolecule detection owing to their parallelizability and
amenability for high-throughput. However, conventional fluorescent microarrays still suffer …

Molecular visualization of early‐stage acute kidney injury with a DNA framework nanodevice

F Ding, S Zhang, S Liu, J Feng, J Li, Q Li… - Advanced …, 2022 - Wiley Online Library
DNA nanomachines with artificial intelligence have attracted great interest, which may open
a new era of precision medicine. However, their in vivo behavior, including early diagnosis …

Intracellular in situ assembly of palindromic DNA hydrogel for predicting malignant invasion and preventing tumorigenesis

S Sun, H Xu, Y Yang, L Wang, L Ye, H Jiang… - Chemical Engineering …, 2022 - Elsevier
DNA structural nanotechnology is of significant importance for the understanding, diagnosis
and treatment of human diseases. However, few reports have examined whether DNA …