Targeting MET in cancer: rationale and progress

E Gherardi, W Birchmeier, C Birchmeier… - Nature reviews …, 2012 - nature.com
Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

Acute bacterial meningitis in infants and children

KS Kim - The Lancet infectious diseases, 2010 - thelancet.com
Bacterial meningitis continues to be an important cause of mortality and morbidity in
neonates and children throughout the world. The introduction of the protein conjugate …

Structural basis of the activation of c-MET receptor

E Uchikawa, Z Chen, GY Xiao, X Zhang… - Nature communications, 2021 - nature.com
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

J Neijssen, RMF Cardoso, KM Chevalier… - Journal of Biological …, 2021 - ASBMB
A bispecific antibody (BsAb) targeting the epidermal growth factor receptor (EGFR) and
mesenchymal–epithelial transition factor (MET) pathways represents a novel approach to …

Illuminating the landscape of host–pathogen interactions with the bacterium Listeria monocytogenes

P Cossart - Proceedings of the National Academy of …, 2011 - National Acad Sciences
Listeria monocytogenes has, in 25 y, become a model in infection biology. Through the
analysis of both its saprophytic life and infectious process, new concepts in microbiology …

Entry of Listeria monocytogenes in mammalian epithelial cells: an updated view

J Pizarro-Cerdá, A Kühbacher… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Listeria monocytogenes is a bacterial pathogen that promotes its internalization into host
epithelial cells. Interaction between the bacterial surface molecules InlA and InlB and their …

Mechanisms of microbial traversal of the blood–brain barrier

KS Kim - Nature Reviews Microbiology, 2008 - nature.com
Central nervous system (CNS) infections continue to be an important cause of morbidity and
mortality. Microbial invasion and traversal of the blood–brain barrier is a prerequisite for …

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent

M Merchant, X Ma, HR Maun, Z Zheng… - Proceedings of the …, 2013 - National Acad Sciences
Binding of hepatocyte growth factor (HGF) to the receptor tyrosine kinase MET is implicated
in the malignant process of multiple cancers, making disruption of this interaction a …

Role of internalin proteins in the pathogenesis of Listeria monocytogenes

K Ireton, R Mortuza, GC Gyanwali… - Molecular …, 2021 - Wiley Online Library
Listeria monocytogenes is a food‐borne bacterium that causes gastroenteritis, meningitis, or
abortion. L. monocytogenes induces its internalization (entry) into human cells and either …

Targeting the HGF/Met signaling pathway in cancer therapy

F Cecchi, DC Rabe, DP Bottaro - Expert opinion on therapeutic …, 2012 - Taylor & Francis
Introduction: Under normal conditions, hepatocyte growth factor (HGF)-induced activation of
its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …