Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis

KA Staats, DR Borchelt, MG Tansey… - Molecular …, 2022 - Springer
Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in
which many processes are detected including (neuro) inflammation. Many drugs have been …

The peripheral immune system and amyotrophic lateral sclerosis

PA McCombe, JD Lee, TM Woodruff… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is defined by
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …

Plasma inflammatory cytokines are elevated in ALS

R Tortelli, C Zecca, M Piccininni… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which leads
to death in a median time of 2–3 years. Inflammation has been claimed important to the ALS …

Increased interleukin-6 levels in the astrocyte-derived exosomes of sporadic amyotrophic lateral sclerosis patients

Y Chen, K Xia, L Chen, D Fan - Frontiers in Neuroscience, 2019 - frontiersin.org
Neuroinflammation plays an important role in amyotrophic lateral sclerosis (ALS)
pathogenesis. However, it is difficult to evaluate inflammation of the central nervous system …

The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions

I Kerkis, ÁP Silva, RP Araldi - Frontiers in Immunology, 2024 - frontiersin.org
Interleukin-6 (IL-6) is a versatile cytokine crucial for immune response modulation,
inflammation regulation, and various physiological processes in the body. Its wide-ranging …

Neuroimmune crosstalk between the peripheral and the central immune system in amyotrophic lateral sclerosis

W Yu, J He, X Cai, Z Yu, Z Zou, D Fan - Frontiers in Aging …, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by the degeneration and
death of motor neurons. Systemic neuroinflammation contributes to the pathogenesis of …

Diaphragmatic neurophysiology and respiratory markers in ALS

M De Carvalho, M Swash, S Pinto - Frontiers in neurology, 2019 - frontiersin.org
The main reason for short survival in amyotrophic lateral sclerosis (ALS) is involvement of
respiratory muscles. Severe compromise of diaphragmatic function due to marked loss of …

Inflammatory checkpoints in amyotrophic lateral sclerosis: From biomarkers to therapeutic targets

Z Jiang, Z Wang, X Wei, XF Yu - Frontiers in Immunology, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron damage. Due to the complexity of the ALS, so far the etiology and …

Biomarkers in amyotrophic lateral sclerosis: A review of new developments

N Verber, PJ Shaw - Current Opinion in Neurology, 2020 - journals.lww.com
Biomarkers in amyotrophic lateral sclerosis: a review of new... : Current Opinion in
Neurology Biomarkers in amyotrophic lateral sclerosis: a review of new developments …

Inflammatory cytokine levels in patients with sporadic amyotrophic lateral sclerosis

Q Sun, Y Huo, J Bai, H Wang, H Wang… - Neurodegenerative …, 2022 - karger.com
Objectives: In the present study, inflammatory factors, including interleukin (IL) and tumor
necrosis factor-α (TNF-α) in the peripheral blood of patients with sporadic amyotrophic …