Non‐small cell lung cancer in China

P Chen, Y Liu, Y Wen, C Zhou - Cancer Communications, 2022 - Wiley Online Library
In China, lung cancer is a primary cancer type with high incidence and mortality. Risk factors
for lung cancer include tobacco use, family history, radiation exposure, and the presence of …

Evolution of systemic therapy for stages I–III non-metastatic non-small-cell lung cancer

JE Chaft, A Rimner, W Weder, CG Azzoli… - Nature reviews Clinical …, 2021 - nature.com
The treatment goal for patients with early-stage lung cancer is cure. Multidisciplinary
discussions of surgical resectability and medical operability determine the modality of …

Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC

M Tsuboi, RS Herbst, T John, T Kato… - … England Journal of …, 2023 - Mass Medical Soc
Background Among patients with resected, epidermal growth factor receptor (EGFR)–
mutated, stage IB to IIIA non–small-cell lung cancer (NSCLC), adjuvant osimertinib therapy …

Perioperative pembrolizumab for early-stage non–small-cell lung cancer

H Wakelee, M Liberman, T Kato, M Tsuboi… - … England Journal of …, 2023 - Mass Medical Soc
Background Among patients with resectable early-stage non–small-cell lung cancer
(NSCLC), a perioperative approach that includes both neoadjuvant and adjuvant immune …

[HTML][HTML] Perioperative nivolumab and chemotherapy in stage III non–small-cell lung cancer

M Provencio, E Nadal… - … England Journal of …, 2023 - Mass Medical Soc
Background Approximately 20% of patients with non–small-cell lung cancer (NSCLC)
receive a diagnosis of stage III disease. There is no current consensus regarding the most …

Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer

PM Forde, J Spicer, S Lu, M Provencio… - … England Journal of …, 2022 - Mass Medical Soc
Background Neoadjuvant or adjuvant chemotherapy confers a modest benefit over surgery
alone for resectable non–small-cell lung cancer (NSCLC). In early-phase trials, nivolumab …

[HTML][HTML] Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial

T Cascone, CH Leung, A Weissferdt, A Pataer… - Nature medicine, 2023 - nature.com
Abstract Neoadjuvant ipilimumab+ nivolumab (Ipi+ Nivo) and nivolumab+ chemotherapy
(Nivo+ CT) induce greater pathologic response rates than CT alone in patients with …

Overall survival and biomarker analysis of neoadjuvant nivolumab plus chemotherapy in operable stage IIIA non–small-cell lung cancer (NADIM phase II trial)

M Provencio, R Serna-Blasco, E Nadal… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Neoadjuvant chemotherapy plus nivolumab has been shown to be effective in
resectable non–small-cell lung cancer (NSCLC) in the NADIM trial (ClinicalTrials. gov …

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

T Cascone, WN William Jr, A Weissferdt, CH Leung… - Nature medicine, 2021 - nature.com
Ipilimumab improves clinical outcomes when combined with nivolumab in metastatic non-
small cell lung cancer (NSCLC), but its efficacy and impact on the immune …

Perioperative nivolumab in resectable lung cancer

T Cascone, MM Awad, JD Spicer, J He… - … England Journal of …, 2024 - Mass Medical Soc
Background Standard treatment with neoadjuvant nivolumab plus chemotherapy
significantly improves outcomes in patients with resectable non–small-cell lung cancer …