B12 deficiency is the leading cause of megaloblastic anemia, and although more common in
the elderly, can occur at any age. Clinical disease caused by B12 deficiency usually …

Abstract Vitamin B 12 (B12; also known as cobalamin) is a B vitamin that has an important
role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial …

Akkermansia muciniphila has evolved to specialize in the degradation and utilization of host
mucus, which it may use as the sole source of carbon and nitrogen. Mucus degradation and …

Background Whether a modestly elevated homocysteine level is causally associated with an
increased risk of cardiovascular disease remains unestablished. We conducted a Mendelian …

Abstract Background Mendelian Randomization (MR) studies assess the causality of an
exposure–disease association using genetic determinants [ie instrumental variables (IVs)] of …

Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …

Measures of B6 status are categorized as direct biomarkers and as functional biomarkers.
Direct biomarkers measure B6 vitamers in plasma/serum, urine and erythrocytes, and …

Background: This review examines the associations between low vitamin B12 levels,
neurodegenerative disease, and cognitive impairment. The potential impact of comorbidities …

The pandemic caused by the new coronavirus has caused shock waves in many countries,
producing a global health crisis worldwide. Lack of knowledge of the biological mechanisms …

To explore the contribution of functional coding variants to psoriasis, we analyzed
nonsynonymous single-nucleotide variants (SNVs) across the genome by exome …