Children differ from adults in many aspects of pharmacotherapy, including capabilities for
drug administration, medicine-related toxicity, and taste preferences. It is essential that …

Background Many active pharmaceutical ingredients taste bitter and thus are aversive to
children as well as many adults. Encapsulation of the medicine in pill or tablet form, an …

Patient acceptability of a medicinal product is a key aspect in the development and
prescribing of medicines. Children and older adults differ in many aspects from the other age …

Objective: A recent double-blind randomized placebo-controlled study demonstrated 3-
month efficacy and safety of a novel pediatric-appropriate prolonged-release melatonin …

Until recently, it was considered unethical or impossible to perform clinical trials of new
medicines in children. As a consequence, many medicines used for treating children are …

Age-adapted drug formulations are a challenge in drug development. This paper describes
the special requirements of paediatric and geriatric patients, and new ideas to solve the …

Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent
slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a …

Many medicines prescribed for children are unlicensed. Solid dosage forms present
problems as children have difficulty swallowing whole tablets or capsules. When medicines …

OBJECTIVE. The goal was to assess the acceptability and suitability of placebo minitablets
for preschool-aged children. METHODS. One hundred children 2 to 6 years of age were …

The formulation of medicines for children remains a challenge. An ideal pediatric formulation
must allow accurate dose administration and be in a dosage form that can be handled by the …