Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Congenital disorders of glycosylation (CDG) are a rapidly growing family of genetic diseases
comprising more than 85 known distinct disorders. They show a great phenotypic variability …

Objective To assess the association of placental abnormalities with neonatal stroke. Study
design This retrospective case-control study at 3 academic medical centers examined …

Blood-brain barrier (BBB) was the major obstacle for efficient delivery of therapeutic agents
to brain tissue. To overcome this barrier, a novel lactoferrin modified long circulation …

The pathophysiology of SCD is multifaceted, as it involves systemwide vascular activation,
altered blood rheology, and the activation of immune responses and coagulative pathways …

Non-arteriosclerotic arteriopathies have emerged as important underlying pathomechanism
in pediatric arterial ischemic stroke (AIS). The pathogenesis and classification of cerebral …

Background and Purpose: Focal cerebral arteriopathy (FCA) of childhood with unilateral
stenosis of the anterior circulation is reported to account for up to one-quarter of childhood …

Background and Purpose—Among children with arterial ischemic stroke (AIS), those with
arteriopathy have the highest recurrence risk. We hypothesized that arteriopathy …

Background Most childhood AIS is associated with nonatherosclerotic cerebral arteriopathy
1, 2—a term encompassing any pathological abnormality of the arterial circulation. This …

This review will discuss important developments in childhood arterial ischemic stroke over
the past decade, focusing on improved understanding of the causes, consequences, and …