Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

[HTML][HTML] The role of IL-1β and TNF-α in intervertebral disc degeneration

Y Wang, M Che, J Xin, Z Zheng, J Li, S Zhang - Biomedicine & …, 2020 - Elsevier
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …

[HTML][HTML] Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

F Chen, G Jiang, H Liu, Z Li, Y Pei, H Wang, H Pan… - Bone research, 2020 - nature.com
The inflammatory response is induced by the overexpression of inflammatory cytokines,
mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration …

[HTML][HTML] Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

Z Chen, H Zhong, J Wei, S Lin, Z Zong, F Gong… - Arthritis research & …, 2019 - Springer
Introduction Osteoarthritis (OA) is an inflammatory disease of the joints that causes
progressive disability in the elderly. Reactive oxygen species (ROS) play an important role …

[HTML][HTML] Bioinformatics-led discovery of osteoarthritis biomarkers and inflammatory infiltrates

X Hu, S Ni, K Zhao, J Qian, Y Duan - Frontiers in immunology, 2022 - frontiersin.org
The molecular mechanisms of osteoarthritis, the most common chronic disease, remain
unexplained. This study aimed to use bioinformatic methods to identify the key biomarkers …

[HTML][HTML] Roles of NLRP3 inflammasome in intervertebral disc degeneration

G Chao-Yang, C Peng, Z Hai-Hong - Osteoarthritis and cartilage, 2021 - Elsevier
Intervertebral disc degeneration (IVDD) is one of the leading causes of low back pain and
one of the most common health problems in the world. The nucleotide-binding …

[HTML][HTML] NLRP3 inflammasome: a new target for prevention and control of osteoporosis?

N Jiang, J An, K Yang, J Liu, C Guan, C Ma… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis is a systemic bone metabolism disease that often causes complications, such
as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain …

[PDF][PDF] Danger signals and inflammaging in osteoarthritis

M Millerand, F Berenbaum, C Jacques - Clin Exp Rheumatol, 2019 - clinexprheumatol.org
Osteoarthritis (OA) is the most common age-related chronic and disabling joint disease.
Long considered to be a “wear and tear” disease, OA is now seen as a low-grade …

[HTML][HTML] Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with …

H Zhou, X Shen, C Yan, W Xiong, Z Ma, Z Tan… - Stem Cell Research & …, 2022 - Springer
Background Osteoarthritis (OA) is a prevalent degenerative joint disease that not only
significantly impairs the quality of life of middle-aged and elderly individuals but also …

Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation

Z Yan, W Qi, J Zhan, Z Lin, J Lin, X Xue… - Journal of Cellular …, 2020 - Wiley Online Library
Osteoarthritis (OA), which is characterized by proliferation of subchondral bone and the
degeneration of articular cartilage, is the most prevalent human arthritis. Nod‐like receptor …