Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Sex differences in movement disorders

S Meoni, A Macerollo, E Moro - Nature Reviews Neurology, 2020 - nature.com
In a range of neurological conditions, including movement disorders, sex-related differences
are emerging not only in brain anatomy and function, but also in pathogenesis, clinical …

The O nset of N onmotor S ymptoms in P arkinson's disease (T he ONSET PD S tudy)

C Pont‐Sunyer, A Hotter, C Gaig, K Seppi… - Movement …, 2015 - Wiley Online Library
Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor
symptoms. Relationship between premotor symptoms onset and motor features is limited …

Premotor and nonmotor features of Parkinson's disease

JG Goldman, R Postuma - Current opinion in neurology, 2014 - journals.lww.com
Premotor and nonmotor features of Parkinson's disease : Current Opinion in Neurology
Premotor and nonmotor features of Parkinson's disease : Current Opinion in Neurology Log in or …

Health‐related quality of life in early Parkinson's disease: The impact of nonmotor symptoms

GW Duncan, TK Khoo, AJ Yarnall… - Movement …, 2014 - Wiley Online Library
Nonmotor symptoms (NMS) are common in patients with established Parkinson's disease
(PD) and have a major impact upon quality of life. We investigated the significance of NMS …

The relevance of gender in Parkinson's disease: a review

M Picillo, A Nicoletti, V Fetoni, B Garavaglia… - Journal of …, 2017 - Springer
Since the official and systematic inclusion of sex and gender in biomedical research, gender
differences have been acknowledged as important determinants of both the susceptibility to …

The concept of prodromal Parkinson's disease

P Mahlknecht, K Seppi… - Journal of Parkinson's …, 2015 - content.iospress.com
Parkinson's disease (PD) is currently clinically defined by a set of cardinal motor features
centred on the presence of bradykinesia and at least one additional motor symptom out of …

The impact of non‐motor symptoms on the quality of life of Parkinson's disease patients: a longitudinal study

KM Prakash, NV Nadkarni, WK Lye… - European journal of …, 2016 - Wiley Online Library
Background and purpose Non‐motor symptoms (NMS s) are common amongst patients with
Parkinson's disease (PD); however, little is known about their influence on the health …

Neuroimaging of Parkinson's disease: Expanding views

CP Weingarten, MH Sundman, P Hickey… - … & Biobehavioral Reviews, 2015 - Elsevier
Advances in molecular and structural and functional neuroimaging are rapidly expanding
the complexity of neurobiological understanding of Parkinson's disease (PD). This review …

The heterogeneity of early Parkinson's disease: a cluster analysis on newly diagnosed untreated patients

R Erro, C Vitale, M Amboni, M Picillo, M Moccia… - PloS one, 2013 - journals.plos.org
Background The variability in the clinical phenotype of Parkinson's disease seems to
suggest the existence of several subtypes of the disease. To test this hypothesis we …