Activation and role of astrocytes in ischemic stroke

XY Shen, ZK Gao, Y Han, M Yuan, YS Guo… - Frontiers in cellular …, 2021 - frontiersin.org
Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various
reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant …

Neuroinflammation in the central nervous system: Symphony of glial cells

Q Yang, J Zhou - Glia, 2019 - Wiley Online Library
Neuroinflammation in the central nervous system (CNS) is an important subject of
neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key …

The contribution of astrocytes and microglia to traumatic brain injury

IP Karve, JM Taylor, PJ Crack - British journal of pharmacology, 2016 - Wiley Online Library
Traumatic brain injury (TBI) represents a major cause of death and disability in developed
countries. Brain injuries are highly heterogeneous and can also trigger other neurological …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics

ML Pearn, IR Niesman, J Egawa, A Sawada… - Cellular and molecular …, 2017 - Springer
Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

A Kumar, DJ Loane - Brain, behavior, and immunity, 2012 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

Y Zhou, A Shao, Y Yao, S Tu, Y Deng… - Cell Communication and …, 2020 - Springer
Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide.
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

D Shlosberg, M Benifla, D Kaufer… - Nature Reviews …, 2010 - nature.com
Traumatic brain injury (TBI) is the leading cause of death in young adults and children. The
treatment of TBI in the acute phase has improved substantially; however, the prevention and …

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

DJ Loane, AI Faden - Trends in pharmacological sciences, 2010 - cell.com
Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …

Mitochondria in traumatic brain injury and mitochondrial‐targeted multipotential therapeutic strategies

G Cheng, R Kong, L Zhang… - British journal of …, 2012 - Wiley Online Library
Traumatic brain injury (TBI) is a major health and socioeconomic problem throughout the
world. It is a complicated pathological process that consists of primary insults and a …